Acetylsalicylic acid definition of acetylsalicylic acid by. Download as ppt, pdf, txt or read online from scribd. Full text get a printable copy pdf file of the complete article 202k, or click on a page image below to browse page by page. It is also soluble in ethanol at 50 mgml and will dissolve in solutions of alkali hydroxides and carbonates with decomposition. Zirconium phosphate nanoparticles for solvent free acetylation of. In folk medicine, willow bark teas were used as headache remedies and other tonics. In this lab, we synthesized aspirin using both acid catalysis and base catalysis. Pdf preparing a pure aspirin acetylsalicylic acid researchgate. What we first did was make the 100 ml aspirin solution up by using a mortar and pestle to grind up the tablet and then we dissolved the aspirin.
E29 preparation of aspirin acetylsalicylic acid and thin. Your team of scientists has been hired by the drug research division of santa monica. Also,one mol of oh reacts with one mole of acetylsalicylic acid. It enters the bloodstream where it interferes with the synthesis of prostaglandins and irreversibly binds to an enzyme called cyclooxygenase 2. In the us, acetylsalicylic acid is a member of the following drug classes.
You reacted salicylic acid and acetic anhydride to form aspirin, or acetylsalicylic acid. Synthesis of acetylsalicylic acid aspirin from salicylic acid and acetic anhydride soriano, sosa, sualibios and tan department of chemistry, college of science, university of santo tomas, manila abstract this experiment was done in order to synthesize aspirin from the fischer esterification reaction of salicylic acid and acetic anhydride. Jul 27, 2017 acetylsalicylic acid get uptodate information on acetylsalicylic acid side effects, uses, dosage, overdose, pregnancy, alcohol and more. Oct 01, 1982 see the reply reactions to acetylsalicylic acid on page 562b. Aspirin hc9h7o4 or c9h8o4 cid 2244 structure, chemical names, physical and chemical properties. Synthesis of acetylsalicylic acid occurs by protonation of carbonyl co gr. Salicylic acid, whose name comes from salix, the willow family of plants, was derived from willow bark extracts.
The skills by the end of the experiment you should be able to. Apr 27, 2019 along with its needed effects, aspirin the active ingredient contained in acetylsalicylic acid may cause some unwanted effects. Jan 21, 2016 in this video the synthesis of acetylsalicylic acid is shown. In some countries, this medicine may only be approved for veterinary use. The average tablet contains about 325 milligrams of the active ingredient acetylsalicylic acid combined with an inert binding material such as starch. Although not all of these side effects may occur, if they do occur they may need medical attention. Media in category acetylsalicylic acid the following 59 files are in this category, out of 59 total. Salicylic acid has the formula c6h4ohcooh, where the oh group is ortho to the carboxyl group. Aspirin is only found in individuals who have consumed this drug. Aspirin is a trade name for acetylsalicylic acid, a common analgesic.
O acetylsalicylic acid is the prototypical analgesic used in the treatment of mild to moderate pain. Specific inflammatory conditions which aspirin is used to treat include kawasaki disease, pericarditis, and rheumatic fever. The synthesis of aspirin has been a popular experiment in organic chemistry. The products of the reaction between salicylic acid and acetic anhydride are acetylsalicylic acid and acetic acid3. Major uses acetylsalicylic acid asa is analgesic, antipyretic and antiinflammatory drug. The first known use of an aspirinlike preparation can be traced to ancient greece and rome.
The earliest known uses of the drug can be traced back to the greek physician hippocrates in the fifth century b. Acetylsalicylic acid is slightly soluble in water, with a limit of solubility reported as approximately 3 mgml at 25 deg c. Choose from 77 different sets of asprin flashcards on quizlet. Acetylsalicylic acid does not have the bad taste and stomach problems of salicylic acid. Synthesis of acetylsalicylic acid essay free essays, term. View enhanced pdf access article on wiley online library html view download pdf for offline viewing. Similarly, the laboratory journal of felix hoffmann, in which he described the synthesis. Ive tried researching on the net and so far i havent really got it, but i think im onto something. Organic chemistry ii january 30, 20 synthesis of aspirin acetylsalicylic acid using acid and base catalysis. Pdf the paper deals with an alternative route for the synthesis of nacetylp aminophenol paracetamol, par and acetylsalicylic acid. Why would it not be a satisfactory catalyst in this reaciton. For this reason, it is industrially synthesized on a massive scale, producing up to 1800 kg 10,000 moles per batch.
It results from the elimination of a molecule of water from two molecules of acetic acid see fig. It is also known as 2hydroxybenzenecarboxylic acid. This experiment involves an ester of this type, a substance commonly called aspirin or acetylsalicylic acid. Calculate the molar mass of salicylic acid, c7h6o3. This aim of this experiment focuses on the synthesis of pure aspirin acetylsalicylic acid from ethanoic anhydride and salicylic acid while using concentrated sulfuric acid as a catalyst for the. Acetylsalicylic acid is an acetic acid ester derivative of salicylic acid. It is widely used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an antiinflammatory medication. A new derivative of acetylsalicylic acid and carnosine. It is used quite often as an introduction to preparative organic chemistry. Aspirin is the common name for the compound acetylsalicylic acid, widely used as a fever reducer and as a pain killer. Aspirin is the active component in headache pills and. Dec 12, 2005 i know that acetylsalicylic acid isnt very soluble in water. Synthesis and purification of acetylsalicylic acid asa or.
Acetylsalicylic acid was synthesized by gerhardt in 1853 and even put on the market during the. Acidbase determination of acetylsalicylic acid in tablets. Synthesis of acetylsalicylic acid dan jones, josh schmidt abstract acetylsalicylic acid, commonly known as aspirin, is considered to be the most successful pharmaceutical product in the world. Aspirin is the most widely used overthecounter drug in the world. The balanced chemical reaction of the formation of aspirin. Short article one hundred years of aspirin europe pmc. After considerable work, the derivative acetylsalicylic acid was found to have similar pain.
Dec 11, 2011 synthesis and purification of acetylsalicylic acid asa or aspirin background salicylic acid is a phenol as well as a carboxylic acid. Hydrochloric acid is about as storng a mineral acid as sulfuric acid. Once acetylsalicylic acid is absorbed from the intestine, it is converted back to salicylic acid. Salicylic acid peels can also help keep pores clean to treat and prevent acne. You were directed to use an excess amount of the acetic anhydride so that the amount of aspirin produced would be determined by the amount of salicylic acid reacted. Salicylic is a weak acid with an alcohol functional group attached to it. Acetylsalicylic acid api manufacturers suppliers drug. Solvent free acetylation of phenols and salicylic acid. E29 preparation of aspirin acetylsalicylic acid and thinlayer chromatography of analgesic drugs the task to prepare a pharmaceutical compound and test its purity. This experiment was carried out to see how the hydroxyl group on the benzene ring in salicylic acid reacts with acetic anhydride to form an ester, and to make aspirin. The only other information i know,is that the acetylsalicylic acid reacts with hydroxide ion,from a standardized sodium hydroxide solution. Since salicylic acid contains phenolic and carboxylic acid groups, it was irritating to the mouth, throat, and stomach. Acetylsalicylic acid in aspirin tablets lab the purpose of this lab was for us to find the amount of acetylsalicylic acid in aspirin tablets and compare this experimental value with the true value. Pdf alternative synthesis of paracetamol and aspirin under non.
Salicigen, an extract of willow and poplar bark, has been used as a pain reliever. Acetylsalicylic acid side effects, uses, dosage, overdose. Aspirin or acetylsalicylic acid acetosal is a drug in the family of salicylates, often used as an analgesic against minor pains and aches, antipyretic against fever, and antiinflammatory. Aqueous solutions of acetylsalicylic acid are most stable at ph 2 3, but to assure full. Continuous endtoend production of solid drug dosage forms. Abstract a facile synthesis of zirconium phosphate zp nanoparticles as. It can therefore undergo two different types of esterification reactions, creating an ester either with the hydroxyl or with the acid. Company replaced the phenol group with an ester group. This statement, however, has never been challenged. Aspirin, also known as acetylsalicylic acid asa, is a medication used to reduce pain, fever, or inflammation. Aspirin given shortly after a heart attack decreases the risk of death.
Jan 30, 20 synthesis of aspirin acetylsalicylic acid using acid and base catalysis chm 2211c. Synthesis of aspirin is basically a product from esterification of. First presentation of the twostep flow synthesis of acetylsalicylic acid. Synthesis of acetylsalicylic acid aspirin using acid.
Feb 06, 2010 how many moles of acetylsalicylic acid molarmass 180. Basically i think that acetylsalicylic acid isnt very soluble in water because of its polarity. Coupling flow synthesis with drug formulation via electrospinning. Apr 30, 2008 these questions are related to a lab experiment on the synthesis of acetylsalicylic acid aspirin. A greener approach to aspirin synthesis using microwave irradiation. Today, salicylic acid has become a popular treatment for acne, and is used in chemical peels to improve the appearance of fine lines, wrinkles, blemishes, and sun damage. As the reaction proceeds, the solid salicylic acid disappears and the acetylsalicylic acid product.
Show this safety data sheet to the doctor in attendance. If inhaled if breathed in, move person into fresh air. He used powder extracted from the bark of willows to treat pain and reduce fever. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. In case of skin contact wash off with soap and plenty of water. Water is a polar molecule, and i think acetylsalicylic acid isnt. Check with your doctor immediately if any of the following side effects occur while taking aspirin. Dec 23, 2000 everything that eichengrun claimed in 1949 about the discovery of aspirin is compatible with the chronology of events presented here, which in turn depends to a great extent upon the reliability of the statement by eichengrun that dreser set acetylsalicylic acid aside for 18 months. Thus, salicylic acid is limiting and a maximum of 0. Acid base determination of acetylsalicylic acid in tablets aspirin is the trade name of drugs containing organic chemical compound named acetylsalicylic acid. How do you account for the smell of vinegar when an old bottle of aspirin is opened. Pdf this aim of this experiment focuses on the synthesis of pure aspirin acetylsalicylic acid from ethanoic anhydride and salicylic acid while.